OMBETOXABART

UNII:	F6ZZ6NRY23
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	OMBETOXABART
GSRS Full Record:	F6ZZ6NRY23 i

3054523-85-9
AZD-5148
AZD5148
H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV1-3*01 (82.7%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, 9-G1v21 CH2 Y15.1, T16, E18 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 M15.1>Y (254), S16>T (256), T18>E (258) (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-11*01 (85.3%) -IGKJ2*02 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer 228-228'':231-231'')-bisdisulfide, produced in a cell line of Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa
Immunoglobulin G1 [254-tyrosine,256-threonine,258-glutamic acid], anti-(Clostridium difficile toxin B) (human-Mus musculus monoclonal AZD5148 γ1-chain), disulfide with human-Mus musculus monoclonal AZD5148 κ-chain, dimer
Ombetoxabart
immunoglobulin G1-kappa, anti-[Clostridioides difficile toxin B (TcdB, C. difficile Toxin B)], humanized monoclonal antibody (ombetoxabart)
ombetoxabart [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

OMBETOXABART

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