LIBENUCGENE PARVEC

UNII:	EMR895S25C
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LIBENUCGENE PARVEC
GSRS Full Record:	EMR895S25C i

3044760-95-1
AAVrh79.TBG.M2PCSK9.WPRE.bGH
DNA (recombinant replication-deficient adeno-associated virus serotype rh79 vector ECUR-506A human α1-microglobulin-bikunin precursor enhancer plus human thyroxine binding globulin promoter plus simian virus 40 nuclear localization signal peptide fusion protein with synthetic meganuclease M2PCSK9 codon-optimized transgene plus woodchuck hepatitis virus post-transcriptional regulatory element WPRE plus bovine growth hormone polyadenylation signal plus inverted terminal repeat flanks)
ECUR-506A
LIBENUCGENE PARVEC [USAN]
Libenucgene Parvec
Recombinant non-replicating adeno-associated virus serotype rh79 (rAAVrh79) vector encoding a fusion protein comprising a simian virus 40 (SV40) nuclear localization signal (NLS) joined to an engineered meganuclease (M2PCSK9) targeting a specific 22-base pair sequence in exon 7 of the human proprotein convertase subtilisin/kexin type 9 (PCSK9) gene. Expression of the transgene is under the control of a human thyroxine binding globulin (TBG) promoter and two copies of an alpha 1-microglobulin/bikunin enhancer element, a Woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) and a bovine growth hormone polyadenylation signal. The expression cassette is flanked by AAV2 inverted terminal repeat
libenucgene parvec [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LIBENUCGENE PARVEC

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