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UPINITATUG RILSODOTIN

UNII:E8US1SQ3B5
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:UPINITATUG RILSODOTIN
GSRS Full Record:
E8US1SQ3B5
i

  • 2254119-00-9
  • ANTI-NAPI2B ADC XMT-1536
  • ANTI-NAPI2B/AURISTATIN F-HPA ADC XMT-1536
  • ANTIBODY-DRUG CONJUGATE ADC XMT-1536
  • Immunoglobulin G1 [de-450-lysine], anti-(human sodium-dependent phosphate transport protein 2B) (human-Mus musculus monoclonal XMT-1535 γ1-chain), disulfide with human-Mus musculus monoclonal XMT-1535 κ-chain, dimer, thioether with N-(2-carboxyethyl)carbamates 22-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-5,10,20-trioxo-13,16-dioxa-2,6,9,19-tetraazadocosanoates dextran, oxidized, reduced, esters with N,N-dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-N-[3-[(2S)-2-[[3-(carboxyamino)-1-oxopropyl]amino]-1-oxopropoxy]propyl]-L-phenylalaninamide
  • Q4MDA7821L
  • Upifitamab Rilsodotin
  • Upifitamab rilsodotin [WHO-DD]
  • Upinitatug Rilsodotin
  • XMT-1536
  • immunoglobulin G1-kappa, anti-[Homo sapiens SLC34A2 (solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B)], monoclonal antibody, conjugated, via a thioether bond, to 3 to 5 flexible polymers PHF-BA-EG2-MI-AF-HPA-Ala, each comprising maleimide (MI) bioconjugation linkers and 3 to 4 auristatin F- hydroxypropylamide-L-alanine (AF-HPA-Ala), with a drug ratio of 12:1 to 15:1; gamma1 heavy chain (1-449) [VH (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.12] (26-33.51-58.97-108) (1-119) -glycinyl (120) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 (CH1 R120 (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS K>del (449)) (121-449)], (223-215')-disulfide with kappa light chain (1’-215’) [V-KAPPA (Mus musculus IGKV10-94*01 (84.2%) -IGKJ5*01 (91.7%)/Homo sapiens IGKV1-33*01 (83.2%) -IGKJ2*01 (90.9%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'-107') -arginyl (108') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (154), V101 (192) (109''-215')]; dimer (229-229":232-232")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; conjugated, via a thioether bond, from 3 to 5 flexible biodegradable polymers, poly(l-hydroxymethylethylene hydroxymethyl-formal) (PHF)-BA-EG2-MI-AF-HPA-Ala, each comprising maleimide (MI) conjugation linkers and 3 to 4 cytotoxic auristatin F- hydroxypropylamide-L-alanine (AF-HPA-Ala), with a drug ratio of 12:1 to 15:1
  • upinitatug rilsodotin [INN]




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