MIPLETAMIG

UNII:	DNP8BBW84R
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	MIPLETAMIG
GSRS Full Record:	DNP8BBW84R i

2839556-21-5
ANTI-CD123/CD3 BISPECIFIC ANTIBODY APVO436
APVO-436
APVO436
IG chainscFvkh-G1hCH2CH3-scFvhk Homo sapiens and humanized (1-757) [scFvkh anti-IL3RA Homo sapiens (1-259) [V-KAPPA (Homo sapiens IGKV4-1*01 (99.0%) -IGKJ4*01 (100%), CDR-IMGT [12.3.10] (27-38.56-58.95-104)) (1-114) -20-mer tetrakis(tetraglycyl-seryl) linker (115-134) -VH (Homo sapiens IGHV3-23*01 (98.0%) -(IGHD) -IGHJ3*02 (100%), CDR-IMGT [8.8.17] (160-167.185-192.231-247)) (135-259)] -Homo sapiens IGHG1*01, G1m17,1CH3 D12, L14, G1v14-1 CH2 A1.3, A1.2, A1, G1v20 A105, G1v37 h S5 (hinge 1-15 C5>S (264) (260-274), CH2 L1.3>A (278), L1.2>A (279), G1>A (281), K105>A (366) (275-384), CH3 D12 (400), L14 (402) (385-489), CHS K2>del (490)) (260-490)] -18-mer (seryl-tris(glycyl-seryl)-prolyl-seryl) linker (491-508) -scFvhk anti-CD3E humanized (509-757) [VH (Homo sapiens IGHV1-69*02 (82.7%) -IGHD -IGHJ4*01 (92.9%), CDR-IMGT [8.8.14] (534-541.559-566.605-618)) (509-629) -20-mer tetrakis(tetraglycyl-seryl) linker (630-649) -V-KAPPA (Homo sapiens IGKV1-5*01 (81.5%) -IGKJ4*01 (100%), CDR-IMGT [5.3.9] (676-680.698-700.737-745)) (650-757)]]; dimer (270-270':273-273')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
Immunoglobulin, anti-(human interleukin 3 receptor) (human-Mus musculus monoclonal APVO436 single-chain variable fragment VL-(GGGGS)4-VH) fusion protein with immunoglobulin G1 [5-serine,19-alanine,20-alanine,22-alanine,107-alanine,de-232-lysine] (human γ1-chain hinge region-CH2-CH3-domain) fusion protein with peptide linker [S(GGGGS)3PS] fusion protein with immunoglobulin anti-(human CD3 antigen ε-chain) (human-Mus musculus monoclonal APVO436 single-chain variable fragment VH-(GGGGS)4-VL), dimer
Mipletamig
immunoglobulin IG chain scFvkh-G1hCH2CH3-scFvhk dimer bisdisulfide, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], Homo sapiens and humanized monoclonal antibody, bispecific, tetravalent
mipletamig [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

MIPLETAMIG

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