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BERUZATATUG PELITECAN

UNII:DAW7F54AQE
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:BERUZATATUG PELITECAN
GSRS Full Record:
DAW7F54AQE
i

  • 2948329-91-5
  • Beruzatatug Pelitecan
  • H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV3-30-5*03 (94.9%) -(IGHD) -IGHJ3*02 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 D12 (358), L14 (360) (343-447), CHS (448-449)) (120-449)], (222-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-9*01 (100%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of an average of eight L-cysteinyl residues among 222, 228, 231, 214', 222'', 228'', 231'' and 214''' with 5-[(11S,14S)-11-[4-(dipropylamino)butyl]-1-[(7S)-7-ethyl-7-hydroxy-8,11-dioxo-7,8,11,13-tetrahydro-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]-7,10,13,16-tetraoxo-14-(propan-2-yl)-4-oxa-6,9,12,15-tetraazahenicos-20-yn-21-yl]pyrimidin-2-yl (pelitecan) groups
  • Immunoglobulin G1, anti-(human epidermal growth factor receptor HER3) (human monoclonal YL202 γ1-chain), complex with human monoclonal YL202 κ-chain, dimer, octakis(thioether) with N-[6-(2-mercapto-5-pyrimidinyl)-1-oxo-5-hexyn-1-yl]-L-valyl-N6,N6-dipropyl-L-lysyl-N-[[3-[(7S)-7-ethyl-7,8,11,13-tetrahydro-7-hydroxy-8,11-dioxo-10H-1,3-dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-14-yl]propoxy]methyl]glycinamide
  • beruzatatug pelitecan [INN]
  • immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosin-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, conjugated on an average of eight cysteinyl residues to pelitecan, comprising a linker and a camptothecin derivative (beruzatatug pelitecan)




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