AVRUKIBART

UNII:	D6ZH4E9SP7
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	AVRUKIBART
GSRS Full Record:	D6ZH4E9SP7 i

3083662-10-3
Avrukibart
Immunoglobulin G1 [237-alanine,238-alanine,255-tyrosine,257-threonine,259-glutamic acid], anti-(human interleukin 23A) (human-Mus musculus monoclonal ORKA-001 γ1-chain), disulfide with human-Mus musculus monoclonal ORKA-001 κ-chain, dimer
ORKA-001
ORKA001
avrukibart (immunoglobulin G1-kappa, anti-[Homo sapiens IL23A (interleukin 23 subunit alpha; IL-23A, IL-23 subunit p19, IL23p19)], humanized monoclonal antibody)
avrukibart [INN]
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-23*03 (74.2%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 6-G1v14 CH2 A1.3, A1.2, 9-G1v21 CH2 Y15.1, T16, E18 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 L1.3>A (237), L1.2>A (238), M15.1>Y (255), S16>T (257), T18>E (259) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (84.2%) -IGKJ4*01 (91.7%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (CKAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

AVRUKIBART

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