LOTIVIBART

UNII:	CV5TGS48YN
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	LOTIVIBART
GSRS Full Record:	CV5TGS48YN i

2851892-98-1
GSK 3810109A [WHO-DD]
GSK-3810109A
GSK3810109A
H-gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV1-2*02 (59.2%) -(IGHD) -IGHJ1*01 (72.7%) L123>T (117), T125>V (119), S128>A (122), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v24 CH3 L107, S114 (CH1 K120 (219) (123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 D12 (361), L14 (363), M107>L (433), N114>S (439) (346-450), CHS (451-452)) (123-452)], (225-210')-disulfide with L-kappa light chain Homo sapiens (1'-210') [V-KAPPA (Homo sapiens IGKV1-13*02 (69.6%) -IGKJ5*01 (70.0%) Q120>R (96'), T122>S (98'), E1125>H (101'), CDR-IMGT [6.3.5] (27'-32'.50'-52'.89'-93')) (1'-103') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (CKAPPA A45.1 (149'), V101 (187')) (104'-210')]; dimer (231-231'':234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa
Immunoglobulin G1 [433-leucine,439-serine], anti-(human immunodeficiency virus retroviral envelope glycoprotein gp120env CD4-binding site) (human clone VH3810109 γ1-chain), disulfide with human clone VH3810109 κ-chain, dimer
LOTIVIBART [USAN]
Lotivibart
N6LS
N6LS (RECOMBINANT HUMAN IMMUNOGLOBULIN G1 DIRECTED AGAINST THE CD4-BINDING SITE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) GLYCOPROTEIN 120)
VRC-HIVMAB091-00-AB
immunoglobulin G1-kappa, anti-[HIV-1 (human immunodeficiency virus type 1) gp120 envelope glycoprotein, CD4-binding site], Homo sapiens monoclonal antibody
lotivibart [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

LOTIVIBART

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