AFAMITRESGENE AUTOLEUCEL

UNII:	CUY18BJ7BP
Formula:
Preferred Substance Name:	AFAMITRESGENE AUTOLEUCEL

AFAMITRESGENE AUTOLEUCEL [INN]
AFAMITRESGENE AUTOLEUCEL [USAN]
AFAMITRESGENE AUTOLEUCEL [WHO-DD]
AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE HUMAN MELANOMA ANTIGEN A4 (MAGE FAMILY MEMBER A4, ANTIGEN MAGE A4) HLA-A*02 PEPTIDE DRIVEN BY THE ELONGATION FACTOR 1 ALPHA (EF1.ALPHA.) PROMOTER. CELLS EXPRESS LYMPHONODE-HOMING MARKERS CCR7 AND CD62L, CD45 ISOFORMS CD45RA AND CD45R0, CO-STIMULATORY MARKERS CD27 AND CD28, IL-7 RECEPTOR CD127, AND CHEMOKINE RECEPTOR CXCR3. CELLS SECRETE INTERLEUKIN 2 (IL-2), TUMOR NECROSIS FACTOR (TNF-ALPHA, TNF.ALPHA.), INTERFERON GAMMA (INTERFERON .GAMMA., IFN-GAMMA), GRANZYME, INTERLEUKIN 4 (IL-4), INTERLEUKIN 13 (IL-13) AND INTERLEUKIN 17 (IL-17) UPON ACTIVATION
MAGE-A4C1032T

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

AFAMITRESGENE AUTOLEUCEL

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