TEZEMLIMOGENE DAXADENOREPVEC

UNII:	B7N7BR6M4A
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	TEZEMLIMOGENE DAXADENOREPVEC
GSRS Full Record:	B7N7BR6M4A i

2642046-11-3
DNA (recombinant human adenovirus 5 ΔE1AΔE3 vector DNX-2440 simian cytomegalovirus immediate-early promoter-enhancer plus human OX40 ligand gene plus Bos taurus growth hormone polyadenylation signal plus viral fiber protein RGD motif insertion mutein-specifying)
DNX-2440
Tezemlimogene Daxadenorepvec
recombinant conditionally replication-competent oncolytic adenovirus type 5 (Ad5) encoding human immune modulatory protein OX40 ligand (OX40L, CD252, tumor necrosis factor ligand superfamily member 4) under control of the cytomegalovirus (CMV) immediate-early promoter-enhancer and terminated with the bovine growth hormone (bGH) polyadenylation sequence. The OX40L sequence along with the CMV immediate-early promoter and bGH polyadenylation signal is inserted into the Ad5 E3 region, displacing approximately 2.69 kb of the E3 region. Genetic modification also includes a 24 bp deletion in the E1A gene and a 27 bp insertion into the fiber gene which introduces an RGD (Arg-Gly-Asp) motif
tezemlimogene daxadenorepvec [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

TEZEMLIMOGENE DAXADENOREPVEC

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