QUOZOVAMERAN

UNII:	B5TAS8B453
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	QUOZOVAMERAN
GSRS Full Record:	B5TAS8B453 i

3047336-79-5
Quozovameran
RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped Venezuelan equine encephalitis virus nonstructural polyprotein codon-optimized gene plus severe acute respiratory syndrome coronavirus 2 spike glycoprotein [682-glycine,683-serine,685-serine,986-proline,987-proline] omicron JN.1 variant precursor codon-optimized gene plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger mRNA-2425), inner salt
quozovameran [INN]
self-amplifying messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase complex (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformation variant (K982P and V983P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein Omicron variant JN.1 (GISAID entry: EPI_ISL_18872762) containing furin cleavage-inactivating mutations (R678G, R679S and R681S), flanked by 5' and 3' untranslated regions and a 3' polyadenylation (polyA) tail; generation of capped S glycoprotein mRNA is under control of a VEEV subgenomic promoter

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

QUOZOVAMERAN

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