COMEKIBART

UNII:	B343W7ZE23
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	COMEKIBART
GSRS Full Record:	B343W7ZE23 i

2833673-47-3
Comekibart
Comekibart [WHO-DD]
Immunoglobulin G4, [222-proline,428-leucine,435-serine,de-C-terminal-lysine], anti-(human interleukin 4 receptor α) (human-Mus musculus monoclonal MG-K10 γ4-chain), disulfide with human-Mus musculus monoclonal MG-K10 κ-chain, dimer
MG-K10
MGK-10
MGK10
comekibart [INN]
immunoglobulin G4-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, interleukin 13 receptor, CD124)], humanized monoclonal antibody; H-gamma4 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-48*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v24 CH3 L107, S114 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 L92 (311) (233-342), CH3 M107>L (430), N114>S (436) (343-447), CHS K2>del (448)) (123-448)], (136-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (89.5%) -IGKJ2*02 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-114')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

COMEKIBART

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