ANVATABART OPADOTIN

UNII:	B2KH16FA7H
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ANVATABART OPADOTIN
GSRS Full Record:	B2KH16FA7H i

2636710-07-9
ANVATABART OPAFIDOTIN [USAN]
ARX 788 [WHO-DD]
ARX-788
ARX-788 (ANTI-HER2 MAB PAF- MMAF TOXIN OXIME CONJUGATE)
ARX788
Anvatabart Opadotin
Immunoglobulin G1 [121-(4-acetylphenylalanine),de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal Amab788 γ1-chain), disulfide with human-Mus musculus monoclonal Amab788 κ-chain, dimer, 121,121′-dioxime with N-[2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]ethyl]-N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine
Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via a stable covalent linker with the microtubule-disrupting agent opadotin
anvatabart opadotin [INN]
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 A1.4>F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219-233), CH2 (234-343), CH3 D12 (359), L14 (361) (344-448), CHS K2>del (449)) (121-449)], (223-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229":232-232")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa; substituted at C-4 of Phe121 and Phe121'' with two (1Z)-N-{[(13S,16S,19S,20R)-19-[(2S)-butan-2-yl]-22-{(2S)-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-20-methoxy-12,18-dimethyl-14,17,22-trioxo-13,16-di(propan-2-yl)-3,6,9-trioxa-12,15,18-triazadocosan-1-yl]oxy}ethanimidoyl (opadotin) groups

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ANVATABART OPADOTIN

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