VANDEFITEMCEL

UNII:	ABC5EQ6K2Y
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	VANDEFITEMCEL
GSRS Full Record:	ABC5EQ6K2Y i

Vandefitemcel (Human differentiation-restricted descendents (DRCs) of bone-marrow-derived adherent stromal cells (MASCs) isolated from adult donor. To obtain DRCs, MASCs were transiently transfected with a DNA plasmid encoding human Notch-1 intracellular domain (NICD) and expanded in growth media. The transduction does not result in permanent incorporation of the gene into the cells, but does result in changes in a number of proteins and in the methylation pattern of the DNA (there is complete loss of recombinant NICD protein and of the plasmid in the final cell population). The transduction changes the nature of the cells such that they no longer readily differentiate into bone, cartilage or adipose cells, and also results in cells altered in their ability to secrete trophic and chemotactic factors, and extracellular matrix proteins to support damaged neural cells. Cells are positive for mesenchymal stem cell (MSC) markers (CD29, CD90, CD105) and negative for hematopoietic markers (CD31, CD34, CD45))
vandefitemcel [INN]

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

VANDEFITEMCEL

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