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PLENCIFGENE PARVEC

UNII:9SG6QLJ7VJ
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:PLENCIFGENE PARVEC
GSRS Full Record:

  • 2737363-32-3
  • 4D-710
  • 4D-A101.CMV173-CFTRΔR
  • DNA (recombinant replication-defective adeno-associated virus vector 4D-710 cytomegalovirus promoter CMV173 plus human (1-707)-(760-1480)-cystic fibrosis transmembrane conductance regulator codon-optimized gene CFTRΔR plus synthetic polyadenylation signal plus adeno-associated virus 2 inverted terminal repeat flanks-specifying)
  • PLENCIFGENE PARVEC [USAN]
  • Plencifgene Parvec
  • plencifgene parvec [INN]
  • recombinant, non-replicating adeno-associated virus (AAV) vector (with capsid variant A101) encoding codon-optimised human cystic fibrosis transmembrane conductance regulator (CFTR) with the regulatory domain deleted (CFTRΔR), under control of a 173bp cytomegalovirus (CMV173) minimal promoter and a short synthetic polyadenylation signal; flanked by AAV2 inverted terminal repeats. The variant A101 capsid is a chimera consisting primarily of serotype AAV1 but also includin



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