DOVARAFUSP ALFA

UNII:	975DV8MA63
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	DOVARAFUSP ALFA
GSRS Full Record:	975DV8MA63 i

3082355-89-0
Dovarafusp alfa
Dovarafusp alfa (humanized immunoglobulin G1-kappa anti-[human angiopoietin-1 receptor (endothelial tyrosine kinase, tyrosine-protein kinase receptor TIE-2, hTIE2, CD202b, TEK)) fused at the C-terminus of each heavy chain, via peptide linker 446GGGGSGGGGSEPKSSDKTHT465 to a human vascular endothelial growth factor receptor 1 (VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Uniprot P17948) domain 2 fragment (103-206; 466-569 in the current sequence), joined at the C-terminus with a human VEGFR-2 (fetal liver kinase 1, FLK-1, Uniprot P35968) domain 3 fragment (208-308; 570-670 in the current sequence). H-gamma1 heavy chain (1-445) [VH (Homo sapiens IGHV1-46*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.6] (31-35.50-66.99-104)) (1-115) -Homo sapiens IGHG1*01 (CH1 (116-213), hinge (214-228), CH2 L232>A, L233>A, H308>A (229-338), CH3 (339-443), CHS (444-445)) (116-445)], fused at the C-terminus via a peptide linker 446GGGGSGGGGSEPKSSDKTHT465 to a human VEGFR-1 domain 2 fragment (466-569), fused with a human VEGFR-2 domain 3 fragment (570-670), (218-214')-disulfide with L-kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-17*01 -IGKJ2*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa)
Immunoglobulin G1 [232-alanine,233-alanine,308-alanine], anti-(human receptor tyrosine kinase Tie2) (human-Mus musculus clone IGT-302 γ1-chain) fusion protein with peptide linker (synthetic 20-amino acid) fusion protein with vascular endothelial growth factor receptor 1 (human domain 2 fragment) fusion protein with vascular endothelial growth factor receptor 2 (human domain 3 fragment), disulfide with human-Mus musculus monoclonal IGT-302 κ-chain, dimer
dovarafusp alfa [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

DOVARAFUSP ALFA

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