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ENCOBERMINOGENE REZMADENOVEC

UNII:93TLW455ZZ
Formula:
Preferred Substance Name:ENCOBERMINOGENE REZMADENOVEC

  • 2376853-01-7
  • A REPLICATION-DEFICIENT RECOMBINANT ADENOVIRUS, SEROTYPE 5 (AD5), ENCODING MULTIPLE HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ISOFORMS (VEGF121, VEGF165 AND VEGF189) UNDER THE CONTROL OF A CYTOMEGALOVIRUS IMMEDIATE EARLY PROMOTER/ENHANCER (CMV) AND THE SIMIAN VIRUS 40 (SV40) POLYA SEQUENCE. ALTERNATIVE SPLICING PROVIDES MRNA THAT ENCODES THE THREE MAJOR ISOFORMS OF VEGF: VEGF121 (EXONS 1-5 AND 8), VEGF165 (EXONS 1-5, 7 AND 8) AND VEGF189 (EXONS 1-5, 6A, 7 AND 8). THE VEGF TRANSGENE IS INSERTED INTO THE REGION FROM WHICH THE ADENOVIRUS EARLY GENE E1A IS DELETED AND E1B IS PARTIALLY DELETED; THE E3 GENE IS DELETED BETWEEN LATE GENE L5 AND THE EARLY GENE E4
  • A REPLICATION-DEFICIENT RECOMBINANT ADENOVIRUS, SEROTYPE 5, ENCODING MULTIPLE HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ISOFORMS
  • DNA (SYNTHETIC HUMAN ADENOVIRUS 5 VECTOR XC001 HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR-SPECIFYING)
  • ENCOBERMINOGENE REZMADENOVEC [INN]
  • ENCOBERMINOGENE REZMADENOVEC [USAN]
  • XC001
  • XC-001




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