PIVICASIRAN

UNII:	8T3L374QA3
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	PIVICASIRAN
GSRS Full Record:	8T3L374QA3 i

2654847-29-5
ALN-519347 free acid
ALN-PNP free acid
PIVICASIRAN [USAN]
Pivicasiran
RNA, (Am-sp-(2′-deoxy-2′-fluoro)C-sp-Am-Um-Am-(2′-deoxy-2′-fluoro)A-Gm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-Am-Um-Um-Am-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)C-Um-Am-Am-Um-Gm-sp-Gm-sp-Gm), complex with RNA (Cm-sp-Am-sp-Um-Um-Am-Gm-(2′-deoxy-2′-fluoro)G-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)A-Um-Gm-Um-Cm-Um-Um-Am-Um-Gm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)
[(2S,4R)-1-(1-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-16,16-bis({3-[(3-{5-[(2-acetamido-2-deoxy-β-Dgalactopyranosyl) oxy]pentanamido}propyl)amino]-3-oxopropyl}methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl)-4-hydroxypyrrolidin-2-yl]methyl hydrogen all-P-ambo-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methyl-Pthioadenylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-deoxy-2'-fluoroadenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethylguanylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethylcytidylyl-( 3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methyluridylyl-(3'→5')-2'-Omethylguanylyl-( 3'→5')-2'-O-methyluridylate duplex with all-P-ambo-2'-O-methyl-P-thioguanylyl-(5'→3')-2'-Omethyl-P-thioguanylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-Omethyluridylyl-( 5'→3')-2'-O-methyladenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methyluridylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-O-methylcytidylyl-(5'→3')-2'-deoxy-2'-fluorouridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyladenylyl-(5'→3')-2'-deoxy-2'-fluorocytidylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-O-methylguanylyl-(5'→3')-2'-deoxy-2'-fluoroadenylyl-(5'→3')-2'-Omethyladenylyl-( 5'→3')-2'-O-methyluridylyl-(5'→3')-2'-O-methyl-Pthioadenylyl-( 5'→3')-2'-deoxy-2'-fluoro-P-thiocytidylyl-(5'→3')-2'-Omethyladenosine
pivicasiran [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

PIVICASIRAN

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