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EFBALROPENDEKIN ALFA

UNII:8DQ4YVG4D5
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:EFBALROPENDEKIN ALFA
GSRS Full Record:
8DQ4YVG4D5
i

  • 2736449-62-8
  • Efbalropendekin Alfa
  • Interleukin 15 [30-asparagine,64-glutamine,65-aspartic acid] (human) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin G1 [4-serine,18-proline,19-valine,20-alanine,51-lysine,79-glutamic acid,140-glutamic acid,142-methionine,152-aspartic acid,154-serine,202-glutamic acid,205-aspartic acid,212-leucine,218-serine] (human γ1-chain C region C-terminal fragment), (130→81′),(133→84′)-bis(disulfide) 1-65-interleukin 15 receptor subunit α (human) fusion protein with peptide linker (GGGGS) fusion protein with immunoglobulin G1 [4-serine,18-proline,19-valine,20-alanine,51-lysine,140-glutamic acid,141-glutamine,142-methionine,148-lysine,212-leucine,218-serine] (human γ1-chain C region C-terminal fragment)
  • efbalropendekin alfa [INN]
  • human interleukin-15 (IL-15) fragment (1-114) variant (D<sup>30</sup>>N, E<sup>64</sup>>Q, N<sup>65</sup>>D) fused via peptide linker <sup>115</sup>GGGGS<sup>119</sup> to a human immunoglobulin G1 C-terminal Fc fragment (120-350) variant, [Homo sapiens IGHG1*03; hinge: 120-134 (C124S); CH2: 135-243 (E137P, L138V, L139A, G139-140del, S170K, Q198E whereby E137P, L138V, L139A, G139-140del matches IGHG2*02); CH3: 244-348 (L271D, K273S, N287D, Q321E, N324D, M331L, N337S); CHS: 349-350], disulfide bridge with human interleukin-15 receptor subunit alpha fragment (1-65) fused via the 66GGGGS70 peptide linker to a human immunoglobulin G1 Fc fragment (71-301) variant [Homo sapiens IGHG1*03; Hinge: 71-85 C75S); CH2: 86-194 (E88P, L89V, L90A, G90-91del, S121K); CH3: 195-299 (E211Q, S218K, M282L, N288S); CHS: 300-301], disulfide bridged heterodimer, produced in Chinese hamster ovary (CHO-M) cells, glycoform alfa




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