ECLUTATUG

UNII:	78938RG6AM
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ECLUTATUG
GSRS Full Record:	78938RG6AM i

2922054-25-7
ALE.C04
Eclutatug
H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-21*01 (94.9%) -(IGHD) -IGHJ1*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS K2>del (448)) (120-448)], (222-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (84.2%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (228-228'':231-231'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa
Immunoglobulin G1 [de-C-terminal-lysine], anti-(human claudin-1) (human-Rattus norvegicus monoclonal ALE.C04 allotype G1m(3) γ1-chain), disulfide with human-Rattus norvegicus monoclonal ALE.C04 κ-chain, dimer
eclutatug [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens sapiens CLDN1 (claudin-1) conformational epitope of the first extracellular loop (EL1)], humanized monoclonal antibody

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ECLUTATUG

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