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ELUVIXTAMAB

UNII:6Z4B5PJ4OP
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:ELUVIXTAMAB
GSRS Full Record:
6Z4B5PJ4OP
i

  • 1679391-73-1
  • A CD33/CD3 BISPECIFIC T-CELL ENGAGER ANTIBODY FOR ACUTE MYELOID LEUKEMIA THERAPY
  • AMG-330
  • AMG330
  • ELUVIXTAMAB [USAN]
  • IMMUNOGLOBULIN SCFV-SCFV, ANTI-(HOMO SAPIENS CD33 (SIALIC ACID BINDING IG-LIKE LECTIN 3, SIGLEC3, SIGLEC-3, GP67, P67)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON)), MONOCLONAL ANTIBODY SINGLE CHAIN, BISPECIFIC; IG SCFV-SCFV SINGLE CHAIN, ANTI-CD33 AND ANTI-CD3E (1-511) (SCFV-VH-V-KAPPA ANTI-CD33 (1-250) (VH (HOMO SAPIENS IGHV1-18*01 (82.7%)-(IGHD)-IGHJ4*01 (93.3%)) CDR-IMGT (8.8.15) (26-33.51-58.97-111) (1-122)-15-MER TRIS(TETRAGLYCYL-SERYL) LINKER (123-137)-V-KAPPA (HOMO SAPIENS IGKV4-1*01 (83.2%)-IGKJ5*01 (100%)) CDR-IMGT (12.3.9) (164-175.193-195.232-240) (138-250))-6-MER SERYL-TETRAGLYCYL-SERYL LINKER (251-256)-SCFV-VH-V-LAMBDA ANTI-CD3E (257-505) (VH (MUS MUSCULUS IGHV10-1*02 (91.9%)-(IGHD)-IGHJ3*01 (86.7%)/HOMO SAPIENS IGHV3-73*01 (87%)-(IGHD)-IGHJ5*01 (100%)) CDR-IMGT (8.10.16) (282-289.307-316.355-370) (257-381)-15-MER TRIS(TETRAGLYCYL-SERYL) LINKER (382-396)-V-LAMBDA (HOMO SAPIENS IGLV7-43*01 (85.1%)-IGLJ3*02 (100%)) CDR-IMGT (9.3.9) (422-430.448-450.487-495) (397-505))-HEXAHISTIDINE (506-511)), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, NON-GLYCOSYLATED
  • IMMUNOGLOBULIN, ANTI-(HUMAN SIALIC ACID-BINDING IG-LIKE LECTIN 3) (HUMAN MONOCLONAL 1803MNGSSMABC SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN ANTI-(HUMAN CD3 ANTIGEN .EPSILON.-CHAIN) (HUMAN MONOCLONAL 1803MNGSSMABC SINGLE-CHAIN VARIABLE FRAGMENT VH2-(GGGGS)3-VL2)
  • eluvixtamab [INN]




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