RAGISTOMIG

UNII:	6W6Z6G78V3
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	RAGISTOMIG
GSRS Full Record:	6W6Z6G78V3 i

2763222-58-6
Immunoglobulin G1 [299-alanine], anti-(human programmed death-ligand 1) (human-Mus musculus clone B6 γ1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with immunoglobulin [103-cysteine,174-cysteine] anti-(human tumor necrosis factor receptor TNFRSF9) (human clone 1A10M12 single-chain Fv fragment VL-(GGGGS)4-VH), disulfide with human-Mus musculus clone B6 κ-chain, dimer
Immunoglobulin G1-scFv_L-kappa dimer, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1,PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)] and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T cell antigen ILA, CD137)], humanized monoclonal antibody, bispecific
Ragistomig
Ragistomig [WHO-DD]
fused G1-scFv lambda-heavy heavy chain humanized (1-715) [gamma1 anti-CD274 humanized (1-449) [VH (Homo sapiens IGHV3-48*02 (87.8%) -(IGHD) -IGHJ4*01 (85.7%) L123>T (114), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119)-Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, G1v29 CH2 A84.4 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 N84.4>A (299)(233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)] -15-mer tris(tetraglycyl-seryl) linker (450-464) -scFv lambda-heavy anti-TNFRSF9 humanized scFv-v2 C120 (VL)-C49 (VH) (465-715) [V-LAMBDA (Homo sapiens IGLV1-47*02 (91.8%) -IGLJ2*01 (91.8%) C120 (567), CDR-IMGT [8.3.11] (490-497.515-517.554-564)) (465-574) -20-mer tetrakis(tetraglycyl-seryl) linker (575-594) -VH (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (620-627.645-652.691-704)) (595-715)]]; (222-214')-disulfide with kappa light chain anti-CD274 humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-33*01 (83.2%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'), V101(191') (108'-214')], dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells
ragistomig [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

RAGISTOMIG

Synonyms and Mappings

Resources