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GAMSITABART TOCENTECAN

UNII:6P4HV3YR58
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:GAMSITABART TOCENTECAN
GSRS Full Record:
6P4HV3YR58
i

  • 3040339-19-0
  • An ADC consisting of antibody Hu14.18-IgG1.4(K322A)-delK conjugated to linker-payload βGluc Exatecan with a drug-to-antibody ratio of 8
  • Gamsitabart Tocentecan
  • H-gamma1 heavy chain (1-441) [VH Musmus/Homsap (Mus musculus IGHV1-42*04 (86.5%) -(IGHD) -IGHJ4*01 (92.9%)/Homo sapiens IGHV1-46*01 (71.9%) -(IGHD) -IGHJ5*01 (90.9%) L123>S (108), CDR-IMGT [8.8.6] (26-33.51-58.97-102)) (1-113) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, 1-G1v50 CH2 delE1.4 P1.3, V1.2, A1.1, 5-G1v20 CH2 A105, 6-G1v60 CH2 S115, S116 (CH1 R120 (210) (114-211), hinge 1-15 (212-226), CH2 E1.4>del, L1.3>P (229), L1.2>V (230), G1.1>A (231), K105>A (317), A115>S (325), P116>S (326) (227-335), CH3 E12 (351), M14 (353) (336-440), CHS K2>del (441)) (114-441)], (216-220')-disulfide with L-kappa light chain (1'-220') [V-KAPPA Musmus/Homsap (Mus musculus IGKV1-110*01 (94.0%) -IGKJ5*01 (100%)/Homo sapiens IGKV2D-29*02 (82.0%) -IGKJ2*01 (81.8%) Q120>A (106'), I126>L (112'), CDR-IMGT [11.3.10] (27'-37'.55'-57'.94'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (222-222'':225-225'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa; substituted at the sulfur atoms of an average of eight L-cysteinyl residues among 216, 222, 225, 220', 216'', 222'', 225'' and 220''' with 1-{3-[(2-{5-[({[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]carbamoyl}oxy)methyl]-2-(β- D -glucopyranuronosyloxy)anilino}-2-oxoethyl)amino]-3-oxopropyl}-2,5-dioxopyrrolidin-3-yl (tocentecan) groups
  • Hu 14.18-IgG1.4 (K322A)-delK-βGluc Exatecan
  • gamsitabart tocentecan [INN]
  • immunoglobulin G1-kappa, anti-[Homo sapiens GD2 (disialoganglioside GD2)], monoclonal antibody, conjugated on an average of eight cysteinyl residues to tocentecan, comprising a linker and a camptothecin derivative (exatecan) (gamsitabart tocentecan)




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