GOTISTOBART

UNII:	4R46M31XXP
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	GOTISTOBART
GSRS Full Record:	4R46M31XXP i

2226344-78-9
GOTISTOBART [USAN]
Gamma1 heavy chain humanized (1-454) [VH (Homo sapiens IGHV4-59*01 (86.6%) -(IGHD) -IGHJ4*01(92.9%), CDR-IMGT [8.7.19] (26-33.51-57.96-114)) (1-125)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120CH3 D12, L14, G1v6CH2 A85.4, A118, A119, G1v21CH2 Y15.1, T16, E18 (CH1 K120 (222) (126-223), hinge 1-15 (224-238), CH2 M15.1>Y (260), S16>T(262), T18>E (264), S85.4>A (306), E118>A (341), K119>A (342) (239-348), CH3 D12 (364), L14 (366)(349-453), CHS K2>del (454)) (126-454)], (228-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (84.2%)-IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89- 97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153), V101 (191) (108'-214')]; dimer (234-234'':237-237'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
Gotistobart
Gotistobart (immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4(cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody)
ONC 392 [WHO-DD]
ONC-392
gotistobart [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

GOTISTOBART

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