ANDUSOMERAN

UNII:	4F9QRS7ZV2
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	ANDUSOMERAN
GSRS Full Record:	4F9QRS7ZV2 i

2918977-08-7
Andusomeran
Andusomeran [WHO-DD]
CX-038839
CX-038839 (COVID-19 Omicron subvariant Kraken) prefusion spike protein mRNA
CX-038839 (COVID-19 Omicron subvariant XBB.1.5) prefusion spike protein mRNA
CX-038839 Omicron (XBB.1.5)
RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Gm)-capped all uridine→N1-methylpseudouridine-substituted severe acute respiratory syndrome coronavirus 2 pre-fusion spike glycoprotein [982-proline,983-proline] XBB.1.5 variant plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger CX-038839), inner salt
andusomeran [INN]
messenger RNA (mRNA), 5'-capped, encoding a full-length, codon-optimised pre-fusion stabilised conformation variant (K982P and V983P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (Omicron variant XBB.1.5; based upon GISAID: EPI_ISL_15948646) further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human alpha globin gene (HBA1) modified to contain an identification and ratio (IDR) sequence to enable identification and relative ratio determination of individual RNA components in a multivalent mRNA vaccine, and terminated by a 3' polyadenylation (polyA) tail; contains N<sup>1</sup>-methylpseudouridine instead of uridine (all-U>m <sup>1</sup>Ψ)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

ANDUSOMERAN

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