BARZOLVOLIMAB

UNII:	4B77GX0NA3
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	BARZOLVOLIMAB
GSRS Full Record:	4B77GX0NA3 i

2438203-51-9
BARZOLVOLIMAB [USAN]
Barzolvolimab
Barzolvolimab [WHO-DD]
CDX-0159
Immunoglobulin G1 [233-alanine,234-glutamine,251-tyrosine,253-threonine,255-glutamic acid,321-glutamine,de-C-terminal-lysine], anti-(human receptor tyrosine kinase KIT extracellular domain) (human-Mus musculus monoclonal CDX-0159 γ1-chain), disulfide with human-Mus musculus monoclonal CDX-0159 κ-chain, dimer
barzolvolimab [INN]
immunoglobulin G1-kappa, anti-[Homo sapiens KIT (KIT protooncogene receptor tyrosine kinase, c-kit, c-Kit, SCFR, CD117) extracellular domain], monoclonal antibody; gamma1 heavy chain (1-445) [VH Musmus/Homsap (Mus musculus IGHV1-76*01 (87.8%) -(IGHD) -IGHJ2*01 (93.3%) L124>V (112)/Homo sapiens IGHV1-2*06 (76.5%) -(IGHD) -IGHJ4*01 (93.3%) L123>T (111), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01, G1m17,1, G1v21 CH2 Y15.1, T16, E18, G1v20 CH2 A105 (CH1 K120 (213) (117-214), hinge 1-15 (215-229), CH2 L1.3>A (233), L1.2>Q (234), M15.1>Y (251), S16>T (253), T18>E (255), K105>Q (321) (230-339), CH3 D12 (355), L14 (357) (340-444), CHS K>del (445)) (117-445)], (219-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-15*01 (84.2%) - IGKJ1*01 (90.9%) L124>V (104)/Homo sapiens IGKV1-16*01 (81.1%) - IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') - Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'- 214')]; dimer (225-225'':228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

BARZOLVOLIMAB

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