IGRELIMOGENE LITADENOREPVEC

UNII:	484TEV85XS
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	IGRELIMOGENE LITADENOREPVEC
GSRS Full Record:	484TEV85XS i

2646695-70-5
DNA (recombinant tumor-selective replicating oncolytic adenovirus 5 vector TILT-123 E2F promoter plus human tumor necrosis factor-α fusion with internal ribosome entry site element fusion with human interleukin 2 plus human adenovirus 3 fiber knob protein-specifying)
Igrelimogene litadenorepvec
Igrelimogene litadenorepvec [WHO-DD]
igrelimogene litadenorepvec [INN]
recombinant, replication-competent oncolytic adenovirus type 5 (Ad5) vector encoding human tumour necrosis factor α (TNFα) and human interleukin 2 (IL-2) separated by an internal ribosomal entry site (IRES), inserted into the E3 region deleted for gp19K/6.7K, and under control of the viral E3 promoter. Viral replication is under control of a tumour-selective E2F promoter that is linked to a 24-bp deletion in the adenoviral E1A region. The gene encoding the viral fiber protein is a chimera with an adenovirus (Ad) type 3 knob sequence and an Ad type 5 shaft and tail sequence

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

IGRELIMOGENE LITADENOREPVEC

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