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BAVEBEGENE TOVACIVEC

UNII:47R2ZYV242
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:BAVEBEGENE TOVACIVEC
GSRS Full Record:
47R2ZYV242
i

  • 2857059-65-3
  • Bavebegene Tovacivec
  • DNA (recombinant modified Vaccinia virus Ankara-derived vaccine vector MVA-HBV endogenous F11 promoter plus hepatitis B virus C-terminal fragment of pre-S1 protein fused with pre-S2 protein fused with non-functional polymerase fused with pre-C protein fused with core antigen plus vaccinia virus early termination signal plus modified H5 promoter plus hepatitis B virus N-terminal fragment of pre-S1 protein fused with surface antigen transgene reverse-complementary)
  • bavebegene tovacivec [INN]
  • recombinant non-replicating vaccinia virus (Modified Vaccinia Ankara strain [MVA]) encoding two codon-optimised fusion proteins adjacent to one another containing hepatitis B virus (HBV) antigens, with the first one comprising the C-terminal region of the HBV Pre-S1 protein, Pre-S2, a non-functional polymerase, the precore antigen, and the core antigen, preceded by a shark Invariant (SIi) chain sequence and under control of the endogenous MVA F11 promoter and the vaccinia virus early termination signal. The second fusion protein comprises the signal peptide from tissue plasminogen activator (tpA), the N-terminal fragment of the HBVPre-S1 protein, and the HBV surface antigen (HBsAg) under control of a modified H5 promoter




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