VUSOLIMOGENE ODERPAREPVEC

UNII:	45KLN7N6UV
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	VUSOLIMOGENE ODERPAREPVEC
GSRS Full Record:	45KLN7N6UV i

2305659-09-8
DNA (Herpes simplex virus type 1 strain RH018A (Accession Number ECCAC 16121904)-derived construct RP1 protein ICP34.5 gene RL1 deletions plus protein ICP47 gene US12 deletion-containing plus human granulocyte macrophage colony stimulating factor codon-optimized gene plus gibbon ape leukemia virus R-transmembrane peptide-deleted fusogenic glycoprotein codon-optimized gene-expressing)
GENETICALLY MODIFIED HSV-1 ONCOLYTIC IMMUNOTHERAPEUTIC RP1
HSV-1 ONCOLYTIC VIRAL STRAIN RP1
ONCOLYTIC VIRUS RP1
RP-1
RP1
RP1 is a selectively replication competent herpes simplex type-1 virus (HSV-1). RP1 was constructed using a new strain of HSV-1 (strain RH018). The neurovirulence factor (ICP34.5)- encoding genes and the ICP47-encoding gene are deleted from the virus. The virus contains the codon-optimized sequence for human granulocyte-macrophage colony stimulating factor (hGM- CSF), a cytokine involved in the stimulation of immune responses and the codon optimized sequence for gibbon ape leukemia virus fusogenic glycoprotein (GALV-GP-R-). The truncated A- version provides constitutive fusion activity. RP1 is intended for direct injection into solid tumors.
VUSOLIMOGENE ODERPAREPVEC [USAN]
Vusolimogene Oderparepvec
Vusolimogene Oderparepvec [WHO-DD]
vusolimogene oderparepvec [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

VUSOLIMOGENE ODERPAREPVEC

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