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VUSOLIMOGENE ODERPAREPVEC

UNII:45KLN7N6UV
Formula:
Preferred Substance Name:VUSOLIMOGENE ODERPAREPVEC

  • 2305659-09-8
  • DNA (HERPES SIMPLEX VIRUS TYPE 1 STRAIN RH018A (ACCESSION NUMBER ECCAC 16121904)-DERIVED CONSTRUCT RP1 PROTEIN ICP34.5 GENE RL1 DELETIONS PLUS PROTEIN ICP47 GENE US12 DELETION-CONTAINING PLUS HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR CODON-OPTIMIZED GENE PLUS GIBBON APE LEUKEMIA VIRUS R-TRANSMEMBRANE PEPTIDE-DELETED FUSOGENIC GLYCOPROTEIN CODON-OPTIMIZED GENE-EXPRESSING)
  • GENETICALLY MODIFIED HSV-1 ONCOLYTIC IMMUNOTHERAPEUTIC RP1
  • HSV-1 ONCOLYTIC VIRAL STRAIN RP1
  • ONCOLYTIC VIRUS RP1
  • RP1
  • RP-1
  • RP1 IS A SELECTIVELY REPLICATION COMPETENT HERPES SIMPLEX TYPE-1 VIRUS (HSV-1). RP1 WAS CONSTRUCTED USING A NEW STRAIN OF HSV-1 (STRAIN RH018). THE NEUROVIRULENCE FACTOR (ICP34.5)- ENCODING GENES AND THE ICP47-ENCODING GENE ARE DELETED FROM THE VIRUS. THE VIRUS CONTAINS THE CODON-OPTIMIZED SEQUENCE FOR HUMAN GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (HGM- CSF), A CYTOKINE INVOLVED IN THE STIMULATION OF IMMUNE RESPONSES AND THE CODON OPTIMIZED SEQUENCE FOR GIBBON APE LEUKEMIA VIRUS FUSOGENIC GLYCOPROTEIN (GALV-GP-R-). THE TRUNCATED A- VERSION PROVIDES CONSTITUTIVE FUSION ACTIVITY. RP1 IS INTENDED FOR DIRECT INJECTION INTO SOLID TUMORS.
  • VUSOLIMOGENE ODERPAREPVEC [INN]
  • VUSOLIMOGENE ODERPAREPVEC [USAN]
  • VUSOLIMOGENE ODERPAREPVEC [WHO-DD]




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