MAPLIRPACEPT

UNII:	44D51T6SZH
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	MAPLIRPACEPT
GSRS Full Record:	44D51T6SZH i

2631667-06-4
1-118-Signal regulatory protein α (human) fusion protein with immunoglobulin G4 [128-proline] (human γ4-chain C region C-terminal fragment), dimer
MAPLIRPACEPT [USAN]
Maplirpacept
Maplirpacept [WHO-DD]
PF-07901801
SIRPA-IGG4-FC FUSION PROTEIN TTI-622
SIRPα-IgG4 F
TTI-622
TTI622
human signal-regulatory protein alpha (SIRPα, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1), natural [L14>S, T20>S, T22>I, R24>H, A27>V, G45>A, D65>E, L66>S, N70>E, R77>S, G79>S, D101>del, V102>T101]- variant, N-terminal (1-118)-fragment [binding domain for CD47 (inhibitor of phagocytosis by macrophages)], fused to a C-terminal Fc fragment of human immunoglobulin G4 (119-347), IGHG4*01; hinge 119- 130 [S128>P]-variant; CH2 131-240; CH3 241-345; CHS 346-347; dimer (126-126':129-129')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
maplirpacept [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

MAPLIRPACEPT

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