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PATRITUMAB DERUXTECAN

UNII:3XPI7EG4W8
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:PATRITUMAB DERUXTECAN
GSRS Full Record:
3XPI7EG4W8
i

  • 2227102-46-5
  • ANTI-HER3 ANTIBODY-DRUG CONJUGATE U3 1402
  • Immunoglobulin G1, anti-(human epidermal growth factor receptor HER3) (human monoclonal U3-1287 γ1-chain), complex with human monoclonal U3-1287 κ-chain, dimer, octakis(thioether) with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]glycinamide
  • Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3)], Homo sapiens monoclonal antibody, conjugated to deruxtecan, comprising a linker and a camptothecin derivative; gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-34*01 (99.0%) -(IGHD) - IGHJ2*01 (100%)) [8.7.11] (1-117) - Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 E12 (356), M14 (358) (341-445), CHS (446-447)) (123-452)], (220-220')-disulfide with kappa light chain Homo sapiens (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (95.0%) -IGKJ1*01 (100%)) [12.3.9] (1'-113') - Homo sapiens IGKC*01 (100%) Km3 A45.1 (159), V101 (197) (114'-220')]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO) cell line, glycoform alfa; conjugated, on an average of 8 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative
  • PATRITUMAB DERUXTECAN [JAN]
  • PATRITUMAB DERUXTECAN [USAN]
  • Patritumab Deruxtecan
  • Patritumab deruxtecan [WHO-DD]
  • U3-1402
  • U3-1402A
  • U31402
  • patritumab deruxtecan [INN]




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