AGUBECIMIG

UNII:	3EF7DL4G5Q
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	AGUBECIMIG
GSRS Full Record:	3EF7DL4G5Q i

3081156-14-8
Agubecimig
Immunoglobulin G1 Fab fragment, bispecific, anti-(human vascular endothelial growth factor A/human interleukin-6) (synthetic human monoclonal RG6209 γ1-chain), disulfide with human monoclonal RG6209 κ-chain
agubecimig [INN]
heavy chain Fab VH humanized anti-VEGFA -G1(CH1-10h) (H) (1-223) [VH (Homo sapiens IGHV3-23*04 (76.0%) -(IGHD) -IGHJ6*01 (85.7%) T123>L (110), CDR-IMGT [7.8.9] (26-32.50-57.96-104)) (1-115) -G1(CH1-h) (Homo sapiens IGHG1*01 (100%), G1m17 (CH1 K120 (212) (116-213), hinge 1-10 (214-223)) (116-223)], (218-214')-disulfide with light chain L-kappa humanized anti-IL6 (L') (1'-214') [V-KAPPA (Homo sapiens IGKV1-5*01 (75.6%) -IGKJ2*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107')) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')], produced in Chinese hamster ovary (CHO) cells, cell line CHOK1, non-glycosylated
immunoglobulin Fab VH-G1(CH1-10h)_L-kappa, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)] and anti-[Homo sapiens IL6 (interleukin 6, IL-6), monoclonal antibody Fab humanized, bispecific, bivalent with an anti-VEGFA paratope on the VH side and an anti-IL6 paratope on the VL side

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

AGUBECIMIG

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