AMOSTOMIG

UNII:	2WU34H9RT9
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	AMOSTOMIG
GSRS Full Record:	2WU34H9RT9 i

2889449-09-4
Amostomig
H-gamma1 heavy chain anti-CD47 humanized (1-464) [VH(Homo sapiens IGHV3-23*04 (83.8%) -(IGHD) -IGHJ4*01(92.3%) L123>T (129), CDR-IMGT [8.10.20] (26-33.51-60.104-123)) (1-134)-Homo sapiens IGHG1*01v, G1m17,1>G1m3,1 CH1 R120, CH3 D12, L14, G1v14 CH2A1.3, A1.2, G1v74 CH3 C10, G1v32 CH3 W22 (knob) (CH1 R120 (231) (135-232), hinge 1-15 (233-247), CH2 L1.3>A(251), L1.2>A (252) (248-357), CH3 D12 (373), L14 (375), S10>C (371), T22>W (383) (358-462), CHS (463-464)) (135-464)], (237-215')-disulfide with common L-lambda2 light chain humanized (1'-216') [V-LAMBDA (Homo sapiens IGLV8-61*01 (85.6%) -IGLJ2*01 (90.9%), CDR-IMGT[9.3.10] (26'-34'.52'-54'.91'-100')) (1'-110') -Homo sapiens IGLC2*01 (100%) (111'-216')]
Immunoglobulin G1 [251-alanine,252-alanine], bispecific, anti-(human CD47 antigen) (human-Lama glama monoclonal BCD-106 γ1-chain), disulfide with human-Lama glama monoclonal BCD-106 λ-chain (243→232′),(246→235′),(371→355′)-tris(disulfide) with immunoglobulin G1 [240-alanine,241-alanine] anti-(human programmed death-ligand PD-L1) (human-Lama glama monoclonal BCD-106 γ1-chain) disulfide with human monoclonal BCD-106 λ-chain
Immunoglobulin G1-lambda, anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)] and anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)], humanized monoclonal antibody, bispecific
amostomig [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

AMOSTOMIG

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