FAMZERETCEL

UNII:	2QX977G5YV
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	FAMZERETCEL
GSRS Full Record:	2QX977G5YV i

Famzeretcel
allogeneic human retinal progenitor cells (hRPCs) derived from foetal retina (17-20 weeks gestation). The retinal tissue undergoes dissection and digestion and the obtained cells are grown on fibronectin-coated plates under hypoxic conditions in serum free high nutrient media. The final cell population is characterized by the expression of retinal specification genes (nestin, >95%; Sox2, >85%; Ki67, >50%) and as well as by evidence of differentiation into neurons (neuronal migration protein doublecortin (DCX)) and glia (glial fibrillary acidic protein (GFAP; <5%). The cells secrete osteopontin (OPN), and the secreted OPN together with other trophic factors can give protection to a human retinoblastoma (hRB) cell line treated with a histone deacetylase inhibitor
famzeretcel [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

FAMZERETCEL

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