PASEMNOGENE GLEPARVOVEC

UNII:	2Q4YZ4G35L
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	PASEMNOGENE GLEPARVOVEC
GSRS Full Record:	2Q4YZ4G35L i

2913126-89-1
Capsomere, recombinant adeno-associated virus 9 viral capsid protein VP1 [422-tryptophan,446-phenylalanine] complex with viral capsid protein VP2 [285-tryptophan,309-phenylalanine] complex with viral capsid protein VP3 [220-tryptophan,244-phenylalanine] decamer, hexacontamer, complex with DNA (recombinant adeno-associated virus vector pAAV-SMN1-GeneBeam v2020-03-11 cytomegalovirus enhancer region plus cytomegalovirus promoter region plus human β-globin gene intron fragment plus human survival of motor neuron protein SMN1 codon-optimized gene plus human somatotropin gene polyadenylation signal plus adeno-associated virus 2 inverted terminal repeat flanks) (1:1)
Pasemnogene Gleparvovec
pasemnogene gleparvovec [INN]
recombinant non-replicating adeno-associated virus serotype 9 (AAV9) vector, encoding a codon-optimised human survival of motor neuron 1 (SMN1) gene, under control of the cytomegalovirus (CMV) enhancer/promoter and terminated by a human growth hormone polyadenylation signal, flanked by AAV2 inverted terminal repeats. A human beta-globin intron has been inserted between the promoter and the SMN1 coding region. The virus vector also contains mutations in the viral capsid protein VP1 (F422W and Y446F)

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

PASEMNOGENE GLEPARVOVEC

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