EFTEZIRLEUKIN ALFA

UNII:	2JT3AAX4HJ
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	EFTEZIRLEUKIN ALFA
GSRS Full Record:	2JT3AAX4HJ i

3055295-61-6
Eftezirleukin Alfa
Immunoglobulin G4 [10-proline,16-alanine,17-alanine,148-tryptophan,de-229-lysine] (human γ4-chain hinge-CH2-CH3 fragment) fusion protein with peptide linker (GGGGGS)4 fusion protein with 6-133-interleukin 2 [38-glycine,42-alanine,62-alanine,125-serine] (human), disulfide with immunoglobulin G4 [10-proline,16-alanine,17-alanine,148-serine,150-alanine,189-valine,217-arginine,218-phenylalanine] (human γ4-chain hinge-CH2-CH3 fragment)
eftezirleukin alfa [INN]
human immunoglobulin G4 (IgG4) Fc fragment (h-CH2-CH3-CHS domains) (1-228) [Homo sapiens IGHG4*01 (hinge S10>P (1-12), CH2 F16>A, L17>A (13-122), CH3 T148>W (123-227), CHS K229>del (228-228))] fused via peptide linker 229(GGGGS)4248 to human interleukin-2 (IL-2, IL2, Uniprot: P60568) fragment (6-133, 249-376 in the current sequence) variant (R38>G281 , F42> A285, E62>A305, C125>S368), (8-8':11-11')-bisdisulfide with human immunoglobulin G4(IgG4) Fc fragment (h-CH2-CH3-CHS domains) (1'-229') [Homo sapiens IGHG4*01 (hinge S 10' >P (1'-12'), CH2 F16' >A, 17' >A (13'-122'), CH3 T148' >S, L150' >A, Y 189' >V, H217' >R, Y218' >F (123'-227'), CHS (228'-229'))], produced in Chinese hamster ovary (CHO) cells, cell line CHO-ZN, glycoform alfa

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

EFTEZIRLEUKIN ALFA

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