PRITEBEGENE ZEPADENOVEC

UNII:	2FFJ8WJ6EM
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	PRITEBEGENE ZEPADENOVEC
GSRS Full Record:	2FFJ8WJ6EM i

2857059-64-2
DNA (replication-deficient simian adenoviral Ox1 ΔE1 ΔE3 E4-modified ChAdOx1-HBV vector human cytomegalovirus promoter plus hepatitis B virus pre-C protein fused with core antigen fused with non-functional polymerase fused with C-terminal fragment of pre-S1 protein fused with pre-S2 protein fused with F2A self-cleaving peptide fused with N-terminal fragment of pre-S1 protein fused with hepatitis B virus surface antigen codon-optimized transgene plus bovine growth hormone polyadenylation signal)
Pritebegene Zepadenovec
pritebegene zepadenovec [INN]
replication-deficient chimpanzee adenovirus vector (ChAdOx1-ΔE1 ΔE3 E4-modified), encoding a codon-optimized fusion protein containing multiple hepatitis B virus (HBV) antigens, comprising the HBV pre-core antigen, core antigen, a nonfunctional polymerase, a C-terminal fragment of the HBV Pre-S1 protein and the Pre-S2 protein, all preceded by a shark Invariant (Sli) chain sequence and separated by a self-cleaving foot-andmouth virus F2A peptide sequence from the leader sequence of human tissue plasminogen activator, followed by an N-terminal fragment of the HBV Pre-S1 protein and the HBV surface antigen (HbSAg), under control of a human cytomegalovirus (CMV) promoter and a bovine growth hormone polyadenylation signal. The transgene is inserted in the deleted E1 region of the viral vector genome gene therapy (immune

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UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

PRITEBEGENE ZEPADENOVEC

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