INVIKAFUSP ALFA

UNII:	2E6V84F6FT
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	INVIKAFUSP ALFA
GSRS Full Record:	2E6V84F6FT i

2894138-60-2
Immunoglobulin G1 [351-cysteine,368-serine,370-alanine,409-valine,de-448-glycine,de-C-terminal lysine], anti-(human T cell receptor germline-encoded variable chain Vβ6/β10) (human-Mus musculus monoclonal BKM0259 γ1-chain), disulfide with human-Mus musculus monoclonal BKM0259 κ-chain, (228→149),(231→152),(351→277)-tris(disulfide) with human interleukin 2 fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin G1 [127-alanine,184-cysteine, 196-tryptophan,de-276-glycine,de-C-terminal lysine] (human γ1-chain C region C-terminal fragment)
Invikafusp Alfa
gamma 1 heavy chain (1-447) [VH (Homo sapiens IGHV1-3*01 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.10] (31-35.50-66.99-108)) (1-119) -Homo sapiens IGHG1*03 (CH1 (120-217), hinge (218-232), CH2 N299>A (233-342), CH3 Y351>C, T368>S, L370>A, Y409>V (343-447), CHS G448>del, K449>del) (120-447)], (222-214')-disulfide with kappa light chain (1'-214')[V-KAPPA (Homo sapiens IGKV1-9*01 -IGKJ2*01, CDR-Kabat [11.7.9](24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; (228-149'':231:152'': 351:277'')-trisdisulfide with human interleukin 2 (IL-2, T-cell growth factor) (C125>A)-variant (1-133) fused via (G4S) 2 peptide linker (134-143) to a Fc fragment of human immunoglobulin G1 (144-368) [Homo sapiens IGHG1*03, hinge N-terminal EPKSC deleted (144-153), CH2 N220>A (154-263), CH3 S277>C, T289>W (264-368), CHS G369>del, K370>del] (produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 cells, glycoform alfa)
humanized immunoglobulin G1-kappa anti-(human T cell receptor germline-encoded variable chain Vβ6/β10) monomer disulfide bridged to human interleukin 2 (IL-2, T-cell growth factor) ((C125>A)-variant fused via (G4S)2 peptide linker to immunoglobulin G1 Fc fragment, glycoform alfa
invikafusp alfa [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

INVIKAFUSP ALFA

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