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TENUMOMERAN

UNII:2CJX8CX5ZF
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:TENUMOMERAN
GSRS Full Record:
2CJX8CX5ZF
i

  • 3024099-60-0
  • BNT113 HPV E6
  • RBL015.2
  • RNA (recombinant 5′-[1,2-[m7Gm-(5′→5′)-p-[P(R)]-sp-p-G]]-capped human major histocompatibility complex class I α chain secretory signal peptide plus codon-optimized human papillomavirus 16 E6 protein transgene plus tetanus toxoid T helper epitope P2P16 plus human major histocompatibility complex class I trafficking and cytoplasmic domain-specifying plus 5′- and 3′-untranslated flanking region-containing poly(A)-tailed messenger RBL015.2), inner salt
  • TENUMOMERAN [USAN]
  • Tenumomeran
  • messenger RNA (mRNA), 5' capped (with an anti-reverse cap analogue [ARCA] [m<sub>2</sub><sup>7,2'-O</sup> G+5'ppsp5'G]), encoding codon-optimised human papilloma virus 16 (HPV16) early protein 6 (E6) tumour-associated antigen, preceded by a secretory signal peptide sequence derived from the human major histocompatibility complex (MCH) class I alpha chain, and followed by sequences coding for tetanus toxoid-derived T helper epitopes (P2P16) and a major histocompatibility complex (MHC) class I trafficking domain [MITD], each of them separated by glycine/serine rich linkers. The transgene is flanked by 5' and 3' untranslated regions (UTR) followed by a 3' polyadenylation (polyA) tail. The 5' UTR is derived from human alpha-globin gene and contains an optimised Kozak sequence; the synthetic 3' UTR is a combination of two elements derived from the amino-terminal enhancer of split (AES) mRNA and mitochondrial encoded 12S ribosomal RNA. The polyA tail consists of 30 adenosine residues followed by a 10-nucleotide linker sequence and another 70 adenosine residues
  • tenumomeran [INN]




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