CINREBAFUSP ALFA

UNII:	21Z359Z1CV
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	CINREBAFUSP ALFA
GSRS Full Record:	21Z359Z1CV i

2218515-90-1
(S228>P,F234>A,L235>A) IMMUNOGLOBULIN G4-KAPPA (CHIMERIC HUMAN-MUS MUSCULUS, ANTI-(RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2, ERBB2, HER2)) FUSED ON BOTH HEAVY CHAINS (1-447, 1''-447'') VIA A (G4S)3 LINKER (448-462, 448''-462'') TO A CD137 (TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9, TNFRSF9, 4-1BB)-TARGETING MUTANT (23 EXCHANGED RESIDUES) OF HUMAN LIPOCALIN-2 (NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN, NGAL, ONCOGENE 24P3, SIDEROCALIN) (463-640, 463''-640''): GAMMA4 HEAVY CHAIN FUSED TO LIPOCALIN-2 MUTEIN (1-640) (HOMO SAPIENS VH CH1 CH2 CH3 (HOMO SAPIENS IGHV3-66*01-(IGHD)-IGHJ4*01 (CDRKABATH1: DTYIH (31-35)CDRKABATH2: RIYPTNGYTRYADSVKG (50-66)CDRKABATH3: WGGDGFYAMDY (99-109)) (1-120)-HOMO SAPIENS IGHG4*01 (CH1 (121-218), HINGE (S228>P) (219-230), CH2 (F234>A, L235>A) (231-340), CH3 (341-445), CHS (446-447)) (1-447)-(G4S)3 LINKER (448-462)-HUMAN LIPOCALIN-2 (MUTANT Q28>H, L36>Q, A40>I, I41>R, Q49>I, Y52>M, N65>D, S68>M, L70>K, R72>D, K73>D, D77>M, W79>D, R81>W, C87>S, N96>K, Y100>F, L103>H, Y106>S, K125>F, S127>F, Y132>E, K134>Y (1-178)) (463-640)), (134-214')-DISULFIDE WITH KAPPA LIGHT CHAIN (1'-214') (HOMO SAPIENS VL CL (HOMO SAPIENS IGKV1-39*01-IGKJ1*01 (CDRKABATL1: RASQDVNTAVA (24'-34')CDRKABATL2: SASFLYS (50'-56')CDRKABATL3: QQHYTTPPT (89'-97')) (1'-107')-HOMO SAPIENS IGKC*01 (108'-214'))DIMER (226-226'':229-229'')-BISDISULFIDE
CINREBAFUSP ALFA [USAN]
Cinrebafusp alfa [WHO-DD]
FUS: MAB HUMANIZED (IGG4) S228P, F234A, L235A ANTI P04626 (ERBB2_HUMAN)RPROT P80188 (NGAL_HUMAN) ANTI Q07011 (TNR9_HUMAN) (PRS343)
IMMUNOGLOBULIN G4 (228-PROLINE, 234-ALANINE, 235-ALANINE), ANTI-(HUMAN TYROSINE KINASE RECEPTOR HER2) (HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .GAMMA.4-CHAIN) FUSION PROTEIN PEPTIDE (SYNTHETIC 15-AMINO ACID LINKER) FUSION PROTEIN WITH LIPOCALIN 2 (HUMAN MUTEIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .KAPPA.-CHAIN, DIMER
PRS-343
cinrebafusp alfa [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

CINREBAFUSP ALFA

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