BOTENSILIMAB

UNII:	1Z5YC3ME5N
Type:	INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:	BOTENSILIMAB
GSRS Full Record:	1Z5YC3ME5N i

2408310-37-0
AGEN-1181
AGEN1181
BOTENSILIMAB [USAN]
Botensilimab
Botensilimab [WHO-DD]
Immunoglobulin G1 [240-aspartic acid,331-leucine,333-glutamic acid,de-C-terminal-lysine], anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal AGEN1181 γ1-chain), disulfide with human monoclonal AGEN1181 κ-chain, dimer
Immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CD152)], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV3-21*01 (99.0%) -(IGHD) - IGHJ3*02 (92.9%) M123>L (113)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v8 CH2 D3, L115, E117 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 S3>D (240), A115>L (331), I117>E (333) (232- 341), CH3 E12 (357), M14 (359) (342-446), CHS K>del (447)) (119-447)], (221-214')-disulfide with kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-20*01 (94.8%) -IGKJ1*01 (100%)) CDR-IMGT [6.3.9] (27-32.50-52.89-97) (1'- 107') -Homo sapiens IGKC*01 (100%) Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (227-227'':230- 230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa
botensilimab [INN]

Note

UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any regulatory review or approval. Synonyms and mappings are based on the best public information available at the time of publication. Please report any problems/errors associated with this data to FDA-SRS@fda.hhs.gov.

BOTENSILIMAB

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