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BEZETABART DEBOTANSINE

UNII:0D8BWL78LD
Formula:
Preferred Substance Name:BEZETABART DEBOTANSINE

  • 2763746-70-7
  • ANTI-CD74 ANTIBODY-DRUG CONJUGATE STRO-001
  • BEZETABART DEBOTANSINE [INN]
  • GAMMA1 HEAVY CHAIN (1-454) (VH (HOMO SAPIENS IGHV3-30-5*03 (95.9%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT (8.8.16) (27-34.52-59.98-113)) (1-124) -HOMO SAPIENS IGHG1*03V, G1M3>G1M17, NG1M1 CH1 K120, CH3 E12, M14 (CH1R120>K(221) (125-222), HINGE 1-15 (223-237), CH2 (238-347), CH3 E12 (363), M14 (365), F85.2>F (PAMF) (411) (348-452), CHS (453-454)) (125-454)), (227-215')-DISULFIDE WITH KAPPA LIGHT CHAIN (1'-215') (V-KAPPA (HOMO SAPIENS IGKV1-12*01 (92.6%) -IGKJ4*01 (100%), CDR-IMGT (6.3.9) (28'-33'.51'-53'.90'-98')) (1'-108') -HOMO SAPIENS IGKC*01 (100%), KM3, A45.1 (154'), V101 (192') (109'-215')); DIMER (233-233'':236-236'')-BISDISULFIDE; PRODUCED BY A CELL-FREE PROTEIN EXPRESSION SYSTEM BASED ON ESCHERICHIA COLI LYSATE, NON-GLYCOSYLATED; SUBSTITUTED AT C-4 OF THE L-PHENYLALANYL RESIDUES 411 AND 411'' WITH (8-((2S)-1-(((14S,16S,2R,32S,33S,4S,10E,12E,14R)-86-CHLORO-14-HYDROXY-85 ,14-DIMETHOXY-2,33,7,10-TETRAMETHYL-12 ,6-DIOXO-7-AZA-1(6,4)-(1,3)OXAZINANA-3(2,3)-OXIRANA-8(1,3)-BENZENACYCLOTETRADECAPHANE-10,12-DIEN-4-YL)OXY)-2,3,9-TRIMETHYL-1,4,8,24-TETRAOXO-12,15,18,21-TETRAOXA-3,9,25-TRIAZAOCTACOSAN-28-OYL)-8,9-DIHYDRO-1H(OR 3H)- DIBENZO(B,F)(1,2,3)TRIAZOLO(4,5-D)AZOCIN-1(OR 3)-YL)METHYL (DEBOTANSINE) GROUPS
  • IMMUNOGLOBULIN G1, ANTI-(HUMAN CD74 ANTIGEN) (HUMAN MONOCLONAL SP7219 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL SP7219 .KAPPA.-CHAIN, DIMER, 411,411'-BIS(4-((8-(3-AMINO-1-OXOPROPYL)-8,9-DIHYDROXY-1H(OR 3H)-DIBENZO(B,F)-1,2,3-TRIAZOLO(4,5-D)AZOCIN-1(OR 3)-YL)METHYL)-L-PHENYLALANINE), AMIDE WITH N2'-(20-CARBOXY-6-METHYL-1,5-DIOXO-9,12,15,18-TETRAOXA-6-AZAEICOS-1-YL)-N2'-DEACETYLMAYTANSINE
  • IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS CD74 (MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II INVARIANT CHAIN)), MONOCLONAL ANTIBODY, CONJUGATED AT C-4 OF TWO SPECIFIC PHENYLALANINE RESIDUES WITH N2' -DEACETYLMAYTANSINE VIA A NON CLEAVABLE LINKER
  • SP7675
  • STRO-001
  • STRO-001, A SITE-SPECIFIC ANTI-CD74 ANTIBODY-DRUG CONJUGATE




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