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BEZETABART DEBOTANSINE

UNII:0D8BWL78LD
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:BEZETABART DEBOTANSINE
GSRS Full Record:
0D8BWL78LD
i

  • 2763746-70-7
  • ANTI-CD74 ANTIBODY-DRUG CONJUGATE STRO-001
  • Bezetabart Debotansine
  • Bezetabart Debotansine [WHO-DD]
  • Gamma1 heavy chain (1-454) [VH (Homo sapiens IGHV3-30-5*03 (95.9%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT [8.8.16] (27-34.52-59.98-113)) (1-124) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1R120>K(221) (125-222), hinge 1-15 (223-237), CH2 (238-347), CH3 E12 (363), M14 (365), F85.2>F (pAMF) (411) (348-452), CHS (453-454)) (125-454)], (227-215')-disulfide with kappa light chain (1'-215') [V-KAPPA (Homo sapiens IGKV1-12*01 (92.6%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (28'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (154'), V101 (192') (109'-215')]; dimer (233-233'':236-236'')-bisdisulfide; produced by a cell-free protein expression system based on Escherichia coli lysate, non-glycosylated; substituted at C-4 of the L-phenylalanyl residues 411 and 411'' with {8-[(2S)-1-{[(1<sup>4</sup>S,1<sup>6</sup>S,2R,3<sup>2</sup>S,3<sup>3</sup>S,4S,10E,12E,14R)-8<sup>6</sup>-chloro-1<sup>4</sup>-hydroxy-8<sup>5</sup> ,14-dimethoxy-2,3<sup>3</sup>,7,10-tetramethyl-1<sup>2</sup> ,6-dioxo-7-aza-1(6,4)-[1,3]oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl]oxy}-2,3,9-trimethyl-1,4,8,24-tetraoxo-12,15,18,21-tetraoxa-3,9,25-triazaoctacosan-28-oyl]-8,9-dihydro-1H(or 3H)- dibenzo[b,f][1,2,3]triazolo[4,5-d]azocin-1(or 3)-yl}methyl (debotansine) groups
  • Immunoglobulin G1, anti-(human CD74 antigen) (human monoclonal SP7219 γ1-chain), disulfide with human monoclonal SP7219 κ-chain, dimer, 411,411′-bis[4-[[8-(3-amino-1-oxopropyl)-8,9-dihydroxy-1H(or 3H)-dibenzo[b,f]-1,2,3-triazolo[4,5-d]azocin-1(or 3)-yl]methyl]-L-phenylalanine], amide with N2′-(20-carboxy-6-methyl-1,5-dioxo-9,12,15,18-tetraoxa-6-azaeicos-1-yl)-N2′-deacetylmaytansine
  • Immunoglobulin G1-kappa, anti-[Homo sapiens CD74 (major histocompatibility complex class II invariant chain)], monoclonal antibody, conjugated at C-4 of two specific phenylalanine residues with N2' -deacetylmaytansine via a non cleavable linker
  • SP7675
  • STRO-001
  • STRO-001, A SITE-SPECIFIC ANTI-CD74 ANTIBODY-DRUG CONJUGATE
  • bezetabart debotansine [INN]




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