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EFRANARELAXIN ALFA

UNII:03X92LE3ZC
Type:INGREDIENT SUBSTANCE
Formula:
Preferred Substance Name:EFRANARELAXIN ALFA
GSRS Full Record:
03X92LE3ZC
i

  • 2969217-22-7
  • Efranarelaxin alfa
  • Immunoglobulin G1 [14-phenylalanine,15-glutamic acid,111-serine,134-cysteine,146-tryptophan,de-C-terminal lysine], (human γ1-chain C-region C-terminal fragment) fusion protein with peptide linker ((GGGGS)3GGGGGS) fusion protein with relaxin H2 A-chain (human), (6→6′),(9→9′),(134→129′),(258→257′),(271→269′)-pentakis(disulfide) with immunoglobulin G1 [14′-phenylalanine,15′-glutamic acid,111′-serine,129′-cysteine,146′-serine,148′-alanine,187′-valine,de-C-terminal lysine] (human γ1-chain C-region C-terminal fragment) fusion protein with peptide linker ((GGGGS)3GGGGGS) fusion protein with 2-29-relaxin H2 B-chain (human)
  • efranarelaxin alfa [INN]
  • human immunoglobulin G1 (IgG1) Fc fragment (h-CH2-CH3-CHS domains) (1-226) [Homo sapiens IGHG1*03 (hinge (1-10), CH2 L<sup>14</sup>>F, L<sup>15</sup>>E, P<sup>111</sup>>S (11-120), CH3 S<sup>134</sup>>C, T<sup>146</sup>>W (121-225), CHS K227>del (226))] fused via peptide linker (G<sub>4</sub>S) <sub>3</sub>G<sub>5</sub>S (227-247) to the chain A of human relaxin H2 (RLN2) (1-24, 248-271 in the actual sequence), heterodimer (6-6':9-9':134-129':258-257':271-269')-pentakisdisulfide with human immunoglobulin G1 (IgG1) Fc fragment (h-CH2-CH3-CHS domains) (1'-226') [Homo sapiens IGHG1*03 (hinge (1'-10'), CH2 L<sup>14'</sup>>F, L<sup>15'</sup>>E, P<sup>111'</sup>>S (11'-120'), CH3 T<sup>146'</sup>>S, L<sup>148'</sup>>A, Y<sup>187'</sup>>V (121'-225'), CHS K<sup>227'</sup>>del (226'))] fused via peptide linker (G<sub>4</sub>S) <sub>3</sub>G<sub>5</sub>S (227'-247') to the des-Asp<sup>1</sup>-chain B of human relaxin H2 (RLN2) (2-29, 248'-275' in the actual sequence), produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa




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