What are the factors that limit our ability to interpret the biological/phenotypic effects of genetic variation? Is more data needed (e.g. WGS)? Are additional breakthroughs required?
Asked by Anonymous
Hi-
That is a great question. The short answer is that yes- we need more data. We need more sequence from control individuals without so that we have a better understanding of the extent of variation within the population. Additionally, we need improved models so that we can better understand how non-coding variation impacts phenotypes. Understanding how environmental factors impact disease is also a significant challenge in understanding biological phenotypes.
No comments yet.
The questions, answers and comments posted under this Expert Q&A forum reflect the views of the author(s) and should not be construed to represent views or policies held by the FDA. Experts answer questions at their discretion and thus not all questions may be addressed. The Expert Q&A forum is also not intended to address questions pertaining to medical advice, diagnosis or treatment.